Aortic valve cell seeding into decellularized animal pericardium by perfusion-assisted bioreactor
نویسندگان
چکیده
منابع مشابه
Decellularized aortic homografts for aortic valve and aorta ascendens replacement†
OBJECTIVES The choice of valve prosthesis for aortic valve replacement (AVR) in young patients is challenging. Decellularized pulmonary homografts (DPHs) have shown excellent results in pulmonary position. Here, we report our early clinical results using decellularized aortic valve homografts (DAHs) for AVR in children and mainly young adults. METHODS This prospective observational study incl...
متن کاملAortic Valve Reconstruction Using Autologous Pericardium for Aortic Stenosis.
BACKGROUND To determine the feasibility of original aortic valve reconstruction (AVRec) for patients with aortic stenosis (AS), 416 consecutive cases were reviewed. METHODS AND RESULTS AVRecs for AS were performed for 416 patients from April 2007 through April 2013. All 416 patients were retrospectively reviewed. One hundred and fourteen patients had bicuspid valves and 16 had unicuspid valve...
متن کاملThree-Dimensional Cell Seeding and Culture in Novel Radial-Flow Perfusion Bioreactor
Tissue engineering has been developed as a new approach in regenerating tissues and organs using cells and scaffolds. An important element in successful tissue engineering in vitro is a suitable bioreactor system (Freed and Vunjak-Novakovic 1997). In general, some types of bioreactors have been used for cell culture on polymer scaffolds, namely spinner flasks, rotating vessels, and perfusion sy...
متن کاملComputational model of aortic valve surgical repair using grafted pericardium.
Aortic valve reconstruction using leaflet grafts made from autologous pericardium is an effective surgical treatment for some forms of aortic regurgitation. Despite favorable outcomes in the hands of skilled surgeons, the procedure is underutilized because of the difficulty of sizing grafts to effectively seal with the native leaflets. Difficulty is largely due to the complex geometry and funct...
متن کاملGuidelines for sizing pericardium for aortic valve leaflet grafts.
Surgical repair of the aortic valve with the use of leaflet grafts made from pericardium has been shown to be a viable option, particularly in children, in whom valve replacement has strong disadvantages. We present guidelines for sizing treated autologous pericardium to fabricate a leaflet graft for single-leaflet replacement. Both our clinical experience and experimental evidence indicate tha...
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ژورنال
عنوان ژورنال: Journal of Tissue Engineering and Regenerative Medicine
سال: 2018
ISSN: 1932-6254
DOI: 10.1002/term.2680